Suggested Literature

Eosinophilic Esophagitis: Diagnostic Criteria And Recommendations

The first consensus recommendations for eosinophilic esophagitis were derived from the first symposium held by The International Gastrointestinal Eosinophil Researchers (TIGER), which was comprised of several members of the CCED faculty. These guidelines were published in 2007 as Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment.

These original consensus guidelines for eosinophilic esophagitis were reviewed and updated in 2011 and published as Eosinophilic esophagitis: updated consensus recommendations for children and adults, with several members of the CCED faculty contributing in this endeavor .

Updated 2018: AGREE paper  & AGREE paper – Supplements

Suggested Literature

Doctors who study eosinophils at the leading research centers recommend the following journal articles for more information about research about eosinophilic disorders.


Rothenberg, Marc An Allergic Basis for Abdominal Pain  The New England Journal of Medicine


Kottyan LC, Trimarchi MP, Lu X, Caldwell JM, Maddox A, Parameswaran S, Lape M, D’Mello RJ, Bonfiend M, Ballaban A, Mukkada V, Putnam P, Abonia P, Ben-Baruch Morgenstern N, Eapen AA, Wen T, Weirauch MT, Rothenberg ME Replication and meta-analyses nominate numerous eosinophilic esophagitis risk genes Food Allergy and Gastrointestinal Disease

Hempel T, Raich L, Olsson S, Azouz NP, Klingler AM, Hoffmann M, Pöhlmann S, Rothenberg ME, Noé F Molecular mechanism of inhibiting the SARS-CoV-2 cell entry facilitator TMPRSS2 with camostat and nafamostat. Chemical Science 

Dellon ES, Shaheen O, Koutlas NT, Chang AO, Martin LJ, Rothenberg ME, Jensen ET Early life factors are associated with risk for eosinophilic esophagitis diagnosed in adulthood. Dis Esophagus. 2021

Jacobsen EA, Jackson DJ, Heffler E, Mathur SK, Bredenoord AJ, Pavord ID, Akuthota P, Roufosse F, Rothenberg ME Eosinophil Knockout Humans: Uncovering the Role of Eosinophils Through Eosinophil-Directed Biological Therapies Annu Rev Immunol . 2021


Dellon, Evan, Reed, Craig C., MD, MSCR Corder, S. Ryanne BS Kim, Erin BS, Sanders, Emily MD, Tappata, Manaswita BS, Elurl, Swathi MD, Psychiatric Comorbidities and Psychiatric Medication Use Are Highly Prevalent in Patients With Eosinophilic Esophagitis and Associate With Clinical Presentation   The American Journal of Gastroenterology

Dellon ES, Collins MH, Rothenberg ME, Assouline-Dayan Y, Evans L, Gupta S, Schoepfer A, Straumann A, Safroneeva E, Rodriguez C, Minton N, Hua SY, Hirano I. 12 March 2020 Long-term Efficacy and Tolerability of RPC4046 in an Open-Label Extension Trial of Patients With Eosinophilic Esophagitis Clinical, Gastroenterology, and Hepatology

Hirano I, Safroneeva E, Roumet MC, Comer GM, Eagle G, Schoepfer A, Falk GW Randomised clinical trial: the safety and tolerability of fluticasone propionate orally disintegrating tablets versus placebo for eosinophilic oesophagitis Alimentary Pharmacology & Therapeutics

kuo Hirano 1, Evan S Dellon 2, Jennifer D Hamilton 3, Margaret H Collins 4, Kathryn Peterson 5, Mirna Chehade 6, Alain M Schoepfer 7, Ekaterina Safroneeva 8, Marc E Rothenberg 4, Gary W Falk 9, Yehudith Assouline-Dayan 10, Qiong Zhao 3, Zhen Chen 3, Brian N Swanson 11, Gianluca Pirozzi 11, Leda Mannent 12, Neil M H Graham 3, Bolanle Akinlade 3, Neil Stahl 3, George D Yancopoulos 3, Allen Radin 3 Efficacy of Dupilumab in a Phase 2 Randomized Trial of Adults With Active Eosinophilic Esophagitis Gastroenterology

Chang, Joy,  Reubenstein, Joel Motivations, Barriers, and Outcomes of Patient-Reported Shared Decision Making in Eosinophilic Esophagitis Chang et alDigestive Diseases and Sciences

Pesek, Robbie, Rothenberg, Marc Eosinophilic gastrointestinal disease below the belt. Pesek et al JACI 2020

Aceves, Seema Collins, Margaret, Rothenberg, Marc Advancing patient care through the Consortium of Eosinophilic Gastrointestional Disease Researcher (CEGIR) Aceves et al JACI 2020

Gonsalves, Nirmala Aceves, Seema Diagnosis and treatment of Eosinophilic Esophagitis Gonsalves et al JACI 2020

Shoda, Tetsuo Wen, Ting Caldwell, Julie Molecular, endoscopic, histologic, and circulating biomarker-based diagnosis of eosinophilic gastritis: Multi-study Shoda et al JACI 2020

Greuter, Thomas Hirano, Ikuo Dellon, Evan Emerging therapies for eosinophilic esophagitis Greuter et al JACI 2020


de Rooji, Willemijn, Dellon, Evan, Parker, Claire, Feagan, Brian, Pharmacotherapies for the treatment of Eosinophilic Esophagitis: State of the Art Review Springer Nature Switzerland AG


Dellon, Evan, Katzka, D, Accuracy and Safety of the Cytosponge for assessing Histologic Activity in Eosinophilic Esophagitis: A Two Center Study American Journal of Gastroenterology

Spergel, J, Aceves, S, New developments in patients with eosinophilic gastrointestinal diseases presented at the CEGIR/TIGERS Symposium at the 2018 American Academy of Allergy, Asthma & Immunology Meeting JACI

Dellon, Evan, Katzka, D, Accuracy and Safety of the Cytosponge for assessing Histologic Activity in Eosinophilic Esophagitis: A Two Center StudyAmerican Journal of Gastroenterology

Spergel, J, Aceves, S, New developments in patients with eosinophilic gastrointestinal diseases presented at the CEGIR/TIGERS Symposium at the 2018 American Academy of Allergy, Asthma & Immunology MeetingJACI


Venter C, Mazzocchi A, Maslin K, Agostoni C. Impact of elimination diets on nutrition and growth in children with multiple food allergiesCurr Opin Allergy Clin Immunol.

Kottyan LC, Rothenberg ME. Genetics of eosinophilic esophagitisMucosal Immunol.

Goldberg MR, Elizur A, Nachshon L, Appel MY, Levy MB, Golobov K, Goldberg R, Stein M, Rothenberg ME, Katz Y. Oral immunotherapy-induced gastrointestinal symptoms and peripheral blood eosinophil responsesJ Allergy Clin Immunol.

Mezoff EA, Lin TK, Kaul A, Kocoshis S, Putnam P, Pentiuk S. A procedural and educational experience following creation of an advanced pediatric endoscopy serviceJ Pediatr Gastroenterol Nutr

Litosh VA, Rochman M, Rymer JK, Porollo A, Kottyan LC, Rothenberg ME. Calpain-14 and its association with eosinophilic esophagitisJ Allergy Clin Immunol.

Rozenberg P, Reichman H, Zab-Bar I, Itan M, Pasmanik-Chor M, Bouffi C, Qimron U, Bachelet I, Fulkerson PC, Rothenberg ME, Munitz A. CD300f:IL-5 cross-talk inhibits adipose tissue eosinophil homing and subsequent IL-4 production. Sci Rep.

Wen T, Rothenberg ME. Clinical Applications of the Eosinophilic Esophagitis Diagnostic Panel. Front Med 

Nowak-Węgrzyn A, Chehade M, Groetch ME, Spergel JM, Wood RA, Allen K, Atkins D, Bahna S, Barad AV, Berin C, Brown Whitehorn T, Burks AW, Caubet JC, Cianferoni A, Conte M, Davis C, Fiocchi A, Grimshaw K, Gupta R, Hofmeister B, Hwang JB, Katz Y, Konstantinou GN, Leonard SA, Lightdale J, McGhee S, Mehr S, Sopo SM, Monti G, Muraro A, Noel SK, Nomura I, Noone S, Sampson HA, Schultz F, Sicherer SH, Thompson CC, Turner PJ, Venter C, Westcott-Chavez AA, Greenhawt M. International consensus guidelines for the diagnosis and management of food protein-induced enterocolitis syndrome: Executive summary-Workgroup Report of the Adverse Reactions to Foods Committee, American Academy of Allergy, Asthma & ImmunologyJ Allergy Clin Immunol

Greenhawt M, Venter C. Having your cake and EATing it too: early timing of multiple allergen introduction does not increase the risk of developing food allergy in standard risk, breastfed infantsEvid Based Med.

Groetch M, Venter C, Skypala I, Vlieg-Boerstra B, Grimshaw K, Durban R, Cassin A, Henry M, Kliewer K, Kabbash L, Atkins D, Nowak-Węgrzyn A, Holbreich M, Chehade M; Eosinophilic Gastrointestinal Disorders Committee of the American Academy of Allergy, Asthma and Immunology. Dietary therapy and nutrition management of eosinophilic esophagitis: a work group report of the American Academy of Allergy, Asthma, and ImmunologyJ Allergy Clin Immunol Pract.

Dellon ES, Katzka DA, Collins MH, Hamdani M, Gupta SK, Hirano I. Budesonide oral suspension improves symptomatic, endoscopic, and histologic parameters compared with placebo in patients with eosinophilic esophagitisGastroenterology.

Athanasopoulou P, Deligianni E, Dean T, Dewey A, Venter C. Use of baked milk challenges and milk ladders in clinical practice: a worldwide survey of healthcare professionalsClin Exp Allergy.

Abonia JP, Spergel JM, Cianferoni A. Eosinophilic esophagitis: A primary disease of the esophageal mucosaJ Allergy Clin Immunol Pract

Verma AH, Bueter CL, Rothenberg ME, Deepe GS. Eosinophils subvert host resistance to an intracellular pathogen by instigating non-protective IL-4 in CCR2(-/-) mice  Mucosal Immunol.

Qin M, Wang L, Li F, Yang M, Song L, Tian F, Yukht A, Shah PK, Rothenberg ME, Sharifi BG. Oxidized LDL activated eosinophil polarize macrophage phenotype from M2 to M1 through activation of CD36 scavenger receptor. Atherosclerosis.

Greenhawt M, Fleischer DM, Chan ES, Venter C, Stukus D, Gupta R, Spergel JM. LEAPing through the looking glass: secondary analysis of the effect of skin test size and age of introduction on peanut tolerance after early peanut introductionAllergy.

Caldwell JM, Collins MH, Kemme KA, Sherrill JD, Wen T, Rochman M, Stucke EM, Amin L, Tai H, Putnam PE, Jiménez-Dalmaroni MJ, Wormald MR, Porollo A, Abonia JP, Rothenberg ME. Cadherin 26 is an alpha integrin-binding epithelial receptor regulated during allergic inflammationMucosal Immunol

Rochman M, Travers J, Miracle CE, Bedard MC, Wen T, Azouz NP, Caldwell JM, Kc K, Sherrill JD, Davis BP, Rymer JK, Kaufman KM, Rothenberg ME. Profound loss of esophageal tissue differentiation in eosinophilic esophagitisJ Allergy Clin Immunol.

Jensen ET, Kuhl JT, Martin LJ, Rothenberg ME, Dellon ES. Prenatal, intrapartum, and postnatal factors are associated with pediatric eosinophilic esophagitis. J Allergy Clin Immunol.

O’Shea KM, Aceves SS, Dellon ES, Gupta SK, Spergel JM, Furuta GT, Rothenberg ME. Pathophysiology of Eosinophilic EsophagitisGastroenterology.

Collins, M, Martin, L, Rothenberg, M Newly Developed and Validated Eosinophilic Esophagitis Histology Scoring System and Evidence that it Outperforms Peak Eosinophil Count for Disease Diagnosis and Monitoring Diseases of the Esophagus

Hirano, Ikuo, Spechler, Stuart  White Paper AGA: Drug Development for Eosinophilic Esophagitis. Clin Gastroenterol Hepatol


Davis BP, Rothenberg ME. Mechanisms of Disease of Eosinophilic EsophagitisAnnu Rev Pathol.

Metcalfe, DD, Pawankar, R Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases World Allergy Organ

Chandramouleeswaran, PM Shen, D, Preferential Secretion of Thymic Stromal Lymphopoietin (TSLP) by Terminally Differentiated Esophageal Epithelial Cells: Relevance to Eosinophilic Esophagitis (EoE)PLOS One

Moawad, FJ, Dellon, E Effects of Race and Sex on Features of Eosinophilic Esophagitis.Clin Gastroenterol Hepatol

Watts A, Alexander JA, Gupta SK. Eosinophilic esophagitis: search for noninvasive
techniques for long-term monitoring. Gastrointest Endosc.

Gupta, SK, Vitanza JM, Efficacy and safety of oral budesonide suspension in pediatric patients with eosinophilic esophagitis. Clin Gastroenterol Hepatol

Dellon, Evan, Collins, Margaret, Bonis, Peter, Falk, Gary Substantial Variability in Biopsy Practice Patterns Among Gastroenterologists for Suspected Eosinophilic Gastrointestinal Disorders. Clin Gastroenterol Hepatol

Muir, Amanda, Spergel, Jonathan, Fillon, Sophie Microbiome and its impact on gastrointestinal atopy.Allergy

Morris, David, Stucke, Emily, Martin, Lisa Eosinophil progenitor levels are increased in patients with active pediatric eosinophilic esophagitis J Allergy Clin Immunol

Batista, M, Rothenberg,M, Using Cloud Technology in Rare Disease Research: Interview with CEGIR Principal Investigator.  Using Cloud Technology in Rare Disease Research: Interview with CEGIR Principal Investigator

Collins MH, Martin LJ, Alexander ES, Boyd JT, Sheridan R, He H, Pentiuk S, Putnam PE<, Abonia JP, Mukkada VA, Franciosi JP,Rothenberg ME Newly developed and validated eosinophilic esophagitis histology scoring system and evidence that it outperforms peak eosinophil count for disease diagnosis and monitoring.  International Society for Diseases of the Esophagus.

Efergan, A, Azouz, NP, Klein, O, Noguchi, K, Rothenberg, M, Rab12 Regulates Retrograde Transport of Mast Cell Secretory Granules by Interacting with the RILP-Dynein Complex  J Immunology.

Furuta, Glenn, Wen, T, Lucendo, A, Proton pump inhibtor-responsive oesophageal esophilia: an entity challenging current diagnostic criteria for eosinophilic esophagtitis  Molina-Infante.

Falk, G, Furuta, Glenn, Gonsalves, N, Spergel, J Should wheat, barley, rye, and/or gluten be avoided in a 6-food elimination diet? JACI.

Gonsalves, N , Furuta, G, Atkins, D  Eosinophilic Gastrointestinal Disorders Affect More Than Just the Esophagus JPGN.

Jensen, E,Martin, C, Kappelman, M, Dellon, E, Prevalence of Eosinophilic Gastritis, Gastroenteritis, and Colitis: Estimates From a National Administrative Database JPGN.

Travers J, Rochman M, Miracle CE, Cohen JP, Rothenberg ME. Linking impaired skin barrier function to esophageal allergic inflammation via IL-33J Allergy Clin Immunol.

Venter C, Fleischer DM. Diets for diagnosis and management of food allergy: The role of the dietitian in eosinophilic esophagitis in adults and childrenAnn Allergy Asthma Immunol.

Wen T, Rothenberg ME. The Regulatory Function of EosinophilsMicrobiol Spectr.

Simon D, Cianferoni A, Spergel JM, Aceves S, Holbreich M, Venter C, Rothenberg ME, Terreehorst I, Muraro A, Lucendo AJ, Schoepfer A, Straumann A, Simon HU. Eosinophilic esophagitis is characterized by a non-IgE-mediated food hypersensitivityAllergy.

Davis BP, Stucke EM, Khorki ME, Litosh VA, Rymer JK, Rochman M, Travers J,Kottyan LC, Rothenberg ME. Eosinophilic esophagitis-linked calpain 14 is an IL-13-induced protease that mediates esophageal epithelial barrier impairmentJCI Insight.

Golekoh MC, Hornung LN, Mukkada VA, Khoury JC, Putnam PE, Backeljauw PF. Adrenal Insufficiency after Chronic Swallowed Glucocorticoid Therapy for Eosinophilic EsophagitisJ Pediatr.

Safroneeva E, Straumann A, Coslovsky M, Zwahlen M, Kuehni CE, Panczak R, Haas NA, Alexander JA, Dellon ES, Gonsalves N, Hirano I, Leung J, Bussmann C, Collins MH, Newbury RO, De Petris G, Smyrk TC, Woosley JT, Yan P, Yang GY, Romero Y, Katzka DA, Furuta GT, Gupta SK, Aceves SS, Chehade M, Spergel JM, Schoepfer AM; International Eosinophilic Esophagitis Activity Index Study Group. Symptoms Have Modest Accuracy in Detecting Endoscopic and Histologic Remission in Adults With Eosinophilic EsophagitisGastroenterology.

Davis BP, Epstein T, Kottyan L, Amin P, Martin LJ, Maddox A, Collins MH, Sherrill JD, Abonia JP, Rothenberg ME. Association of eosinophilic esophagitis and hypertrophic cardiomyopathyJ Allergy Clin Immunol


Cianferoni, A, Spergel, K, Muir, A Recent advances in the pathological understanding of eosinophilic esophagitis.Expert Rev Gastroenterol Hepatol

Kc, K, Rothenberg, ME, Sherrill, JD In vitro model for studying esophageal epithelial differentiation and allergic inflammatory responses identifies keratin involvement in eosinophilic esophagitis.PLOS one

Harris,JK, Fang, R Esophageal Microbiome in Eosinophilic EsophagitisPLOS one

Furuta, Glenn, Katzka, David Eosinophilic Esophagitis N Engl J Med

Nguyen, Nathalie, Furuta, Glenn, Menard-Katcher, Calies Recognition and Assessment of Eosinophilic Esophagitis: The Development of New Clinical Outcome Metrics  Gastroenterlogy & Hepatology

Rothenberg, Marc Molecular, genetic, and cellular bases for treating eosinophilic esophagitis. Gastroenterology.

Rajan J, Newbury RO, Anilkumar A, Dohil R, Broide DH, Aceves SS Long-term assessment of esophageal remodeling in patients with pediatric eosinophilic esophagitis treated with topical corticosteroids. JACI.

Mehta P, Furuta GT Eosinophils in Gastrointestinal Disorders: Eosinophilic Gastrointestinal Diseases, Celiac Disease, Inflammatory Bowel Diseases, and Parasitic Infections.. Immunology Allergy Clin North Am.

Kochar B, Dellon E.Management of proton pump inhibitor responsive-esophageal eosinophilia and eosinophilic esophagitis: controversies in treatment approaches. Expert review of gastroenterology & hepatology.

Leung J, Beukema KR, Shen AH. Allergic mechanisms of Eosinophilic oesophagitis. Best
Pract Res Clin Gastroenterol.

Tkachenko E, Rawson R, La E, Doherty TA, Baum R, Cavagnero K, Miyanohara A, Dohil R,
Kurten RC, Aceves SS. Rigid substrate induces esophageal smooth muscle hypertrophy
and eosinophilic esophagitis fibrotic gene expression. J Allergy Clin Immunol.


Schoepfer, AM, Straumann, A Development and Validation of a Symptom-Based Activity Index for Adults with Eosinophilic Esophagitis Gastroenterology

Butz,BK, Wen, T, Furuta, G  Efficacy, dose reduction, and resistance to high-dose fluticasone in patients with eosinophilic esophagitis. Gastroenterology

Rothenberg ME Understand ways to treat, cure eosinophilic gastritis News Medical.

Alexander ES, Martin LJ, Collins MH, Kottyan LC, Sucharew H, He H, Mukkada VA, Succop PA, Abonia JP, Foote H, Eby MD, Grotjan TM, Greenler AJ, Dellon ES, Demain JG, Furuta GT, Gurian LE, Harley JB, Hopp RJ, Kagalwalla A, Kaul A, Nadeau KC, Noel RJ, Putnam PE, von Tiehl KF, Rothenberg ME Twin and family studies reveal strong environmental and weaker genetic cues explaining heritability of eosinophilic esophagitis. JACI.

Jung Y, Rothenberg ME. Roles and regulation of gastrointestinal eosinophils in immunity and disease. J Immunology.

Sherrill JD, Rothenberg ME. Genetic and epigenetic underpinnings of eosinophilic esophagitis. Gastroenterol Clin North Am.


Wen T, Stucke EM, Grotjan TM, Kemme KA, Abonia JP, Putnam PE, Franciosi JP, Garza JM, Kaul A, King EC, Collins MH, Kushner JP, Rothenberg ME. Molecular diagnosis of eosinophilic esophagitis by gene expression profiling. Gastroenterology

Abonia JP, Wen T, Stucke EM, Grotjan T, Griffith MS, Kemme KA, Collins MH, Putnam PE, Franciosi JP, von Tiehl KF, Tinkle BT, Marsolo KA, Martin LJ, Ware SM, Rothenberg ME. High prevalence of eosinophilic esophagitis in patients with inherited connective tissue disorders. JACI

Davis BP, Rothenberg ME. Emerging concepts of dietary therapy for pediatric and adult eosinophilic esophagitis. Expert Rev Clin Immunol.


Hommel KA, Franciosi JP, Hente EA, Ahrens A, Rothenberg ME. Treatment adherence in pediatric eosinophilic gastrointestinal disorders. J Pediatr Psychol. [Epub ahead of print]

Franciosi JP, Hommel KA, Debrosse CW, Greenberg AB, Greenler AJ, Abonia JP, Rothenberg ME, Varni JW. Quality of life in paediatric eosinophilic oesophagitis: what is important to patients? Child Care Health Dev.  [Epub ahead of print]

Spergel JM, Rothenberg ME, Collins MH, Furuta GT, Markowitz JE, Fuchs G 3rd, O’Gorman MA, Abonia JP, Young J, Henkel T, Wilkins HJ, Liacouras CA. Reslizumab in children and adolescents with eosinophilic esophagitis: Results of a double-blind, randomized, placebo-controlled trial. J Allergy Clin Immunol. 2012;129(2):456-463.e3.

Wen T, Mingler MK, Blanchard C, Wahl B, Pabst O, Rothenberg ME. The Pan-B Cell Marker CD22 Is Expressed on Gastrointestinal Eosinophils and Negatively Regulates Tissue Eosinophilia. J Immunol. 2012;188(3):1075-82.

Abonia JP, Rothenberg ME. Eosinophilic Esophagitis: Rapidly Advancing Insights. Annu Rev Med. 2012;18(63):421-34.


Franciosi JP, Hommel KA, Debrosse CW, Greenberg AB, Greenler AJ, Abonia JP, Rothenberg ME, Varni JW. Development of a validated patient-reported symptom metric for pediatric eosinophilic esophagitis: qualitative methods. BMC Gastroenterol. 2011;11:126.

Debrosse CW, Franciosi JP, King EC, Buckmeier Butz BK, Greenberg AB, Collins MH, Abonia JP, Assa’ad A, Putnam PE, Rothenberg ME. Long-term outcomes in pediatric-onset esophageal eosinophilia. J Allergy Clin Immunol. 2011;128(1):132-8.

Sherrill JD, Rothenberg ME. Genetic dissection of eosinophilic esophagitis provides insight into disease pathogenesis and treatment strategies. J Allergy Clin Immunol.
2011;128(1):23-32; quiz 33-4.

Liacouras CA, Furuta GT, Hirano I, Atkins D, Attwood SE, Bonis PA, Burks AW, Chehade M, Collins MH, Dellon ES, Dohil R, Falk GW, Gonsalves N, Gupta SK, Katzka DA, Lucendo AJ, Markowitz JE, Noel RJ, Odze RD, Putnam PE, Richter JE, Romero Y, Ruchelli E, Sampson HA, Schoepfer A, Shaheen NJ, Sicherer SH, Spechler S, Spergel JM, Straumann A, Wershil BK, Rothenberg ME, Aceves SS. Eosinophilic esophagitis: Updated consensus recommendations for children and adults. J Allergy Clin Immunol. 2011; 128(1):3-20.e6; quiz 21-2.

Lacy P, Willetts L, Kim JD, Lo AN, Lam B, Maclean EI, Moqbel R, Rothenberg ME, Zimmermann N. Agonist Activation of F-Actin-Mediated Eosinophil Shape Change and Mediator Release Is Dependent on Rac2. Int Arch Allergy Immunol. 2011;156(2):137-147.

Waddell A, Ahrens R, Steinbrecher K, Donovan B, Rothenberg ME, Munitz A, Hogan SP. Colonic eosinophilic inflammation in experimental colitis is mediated by Ly6C(high) CCR2(+) inflammatory monocyte/macrophage-derived CCL11. J Immunol. 2011;186(10):5993-6003.

Eom CS, Park SM, Myung SK, Yun JM, Ahn JS. Use of acid-suppressive drugs and risk of fracture: a meta-analysis of observational studies. Ann Fam Med. 2011;9(3):257-67.

Eosinophilic Esophagitis by Dr. Glenn Furuta. Reprinted from Food Allergy News, Vol. 20, No. 4, copyright 2011, The Food Allergy & Anaphylaxis Network (FAAN). Posted with permission.

Lim EJ, Lu TX, Blanchard C, Rothenberg ME. Epigenetic regulation of the IL-13-induced human eotaxin-3 gene by CBP-mediated histone 3 acetylation. J Biol Chem. 2011;286(15):13193-13204.

Broide DH, Finkelman F, Bochner BS, Rothenberg ME. Advances in mechanisms of asthma, allergy, and immunology in 2010. J Allergy Clin Immunol. 2011;127(3):689-95.

Baye TM, Butsch Kovacic M, Biagini Myers JM, Martin LJ, Lindsey M, Patterson TL, He H, Ericksen MB, Gupta J, Tsoras AM, Lindsley A, Rothenberg ME, Wills-Karp M, Eissa NT, Borish L, Khurana Hershey GK. Differences in Candidate Gene Association between European Ancestry and African American Asthmatic Children. PLoS One. 2011;6(2):e16522.

Mulder DJ, Justinich CJ. Understanding eosinophilic esophagitis: the cellular and molecular mechanisms of an emerging disease. Mucosal Immunol. 2011:4(2):139-47.

Blanchard C, Stucke EM, Rodriguez-Jimenez B, Burwinkel K, Collins MH, Ahrens A, Alexander ES, Butz BK, Jameson SC, Kaul A, Franciosi JP, Kushner JP, Putnam PE, Abonia JP, Rothenberg ME. A striking local esophageal cytokine expression profile in eosinophilic esophagitis. J Allergy Clin Immunol. 2011;127(1):208-17, 217.e1-7.

Miles MV, Putnam PE, Miles L, Tang PH, Degrauw AJ, Wong BL, Horn PS, Foote HL, Rothenberg ME. Acquired coenzyme Q10 deficiency in children with recurrent food intolerance and allergies. Mitochondrion. 2011;11(1):127-35.

Kwiatek MA, Hirano I, Kahrilas PJ, Rothe J, Luger D, Pandolfino JE. Mechanical properties of the esophagus in eosinophilic esophagitis. Gastroenterology. 2011;140(1):82-90.


Abonia JP, Franciosi JP, Rothenberg ME. TGF-beta1: Mediator of a feedback loop in eosinophilic esophagitis − or should we really say mastocytic esophagitis? J Allergy Clin Immunol. 2010;126(6):1205-7.

Cortina S, McGraw K, deAlarcon A, Ahrens A, Rothenberg ME, Drotar D. Psychological functioning of children and adolescents with eosinophil-associated gastrointestinal disorders. Children’s Health Care. 2010; 39(4):266-78.

Voelker R. Researchers look to genetic analyses for new options in treating food allergy. JAMA. 2010; 304(18):2001.

Straumann A, Conus S, Degen L, Felder S, Kummer M, Engel H, Bussmann C, Beglinger C, Schoepfer A, Simon HU. Budesonide is effective in adolescent and adult patients with active eosinophilic esophagitis. Gastroenterology. 2010;139(5):1526-1537.e1.

Finkelman FD, Boyce JA, Vercelli D, Rothenberg ME. Key advances in mechanisms of asthma, allergy, and immunology in 2009. J Allergy Clin Immunol. 2010;125(2):312-8.

Munitz A, Cole ET, Waddell A, Groschwitz K, Ahrens R, Steinbrecher K, Willson T, Han X, Denson L, Rothenberg ME, Hogan SP. Paired immunoglobulin-like Receptor B (PIR-B) Negatively Regulates Macrophage Activation in Experimental Colitis. Gastroenterology. 2010;139(2):530-41.

Rayapudi M, Mavi P, Zhu X, Pandey AK, Abonia JP, Rothenberg ME, Mishra A. Indoor insect allergens are potent inducers of experimental eosinophilic esophagitis in mice.J Leukoc Biol. 2010; 88(2):337-46.

Zhu X, Wang M, Mavi P, Rayapudi M, Pandey AK, Kaul A, Putnam PE, Rothenberg ME, Mishra A. Interleukin-15 expression is increased in human eosinophilic esophagitis and mediates pathogenesis in mice. Gastroenterology. 2010;139(1):182-93.e7.

Simon HU, Rothenberg ME, Bochner BS, Weller PF, Wardlaw AJ, Wechsler ME, Rosenwasser LJ, Roufosse F, Gleich GJ, Klion AD. Refining the definition of hypereosinophilic syndrome. J Allergy Clin Immunol. 2010;126(1):45-9.

Sherrill JD, Gao PS, Stucke EM, Blanchard C, Collins MH, Putnam PE, Franciosi JP, Kushner JP, Abonia JP, Assa’ad AH, Kovacic MB, Biagini Myers JM, Bochner BS, He H, Hershey GK, Martin LJ, Rothenberg ME. Variants of thymic stromal lymphopoietin and its receptor associate with eosinophilic esophagitis. J Allergy Clin Immunol. 2010;126(1):160-165.

DeBrosse CW, Collins MH, Buckmeier Butz BK, Allen CL, King EC, Assa’ad AH, Abonia JP, Putnam PE, Rothenberg ME, Franciosi JP. Identification, epidemiology, and chronicity of pediatric esophageal eosinophilia, 1982-1999. J Allergy Clin Immunol. 2010;126(1):112-119.

Abonia JP, Blanchard C, Butz BB, Rainey HF, Collins MH, Stringer K, Putnam PE, Rothenberg ME. Involvement of mast cells in eosinophilic esophagitis.J Allergy Clin Immunol. 2010;126(1):140-9.

Simon D, Wardlaw A, Rothenberg, ME. Organ-specific eosinophilic disorders of the skin, lung, and gastrointestinal tract. J Allergy Clin Immunol. 2010; 126(1):3-13;quiz 14-5.

Zuo L, Fulkerson PC, Finkelman FD, Mingler M, Fischetti CA, Blanchard C, Rothenberg, ME. IL-13 induces esophageal remodeling and gene expression by an eosinophil-independent, IL-13R{alpha}2-inhibited pathway.J Immunol. 2010;185(1):660-9.

Caldwell JM, Blanchard C, Collins MH, Putnam PE, Kaul A, Aceves SS, Bouska CA, Rothenberg ME. Glucocorticoid-regulated genes in eosinophilic esophagitis: a role for FKBP51. J Allergy Clin Immunol. 2010;125(4):879-88 e8.

Blanchard C, Stucke EM, Burwinkel K, Caldwell JM, Collins MH, Ahrens A, Buckmeier BK, Jameson SC, Greenberg A, Kaul A, Franciosi JP, Kushner JP, Martin LF, Putnam PE, Abonia JP, Wells SI, Rothenberg ME. Coordinate interaction between IL-13 and epithelial differentiation cluster genes in eosinophilic esophagitis.J Immunol. 2010;184(7):4033-41.

Ingerski LM, Modi AC, Hood KK, Pai AL, Zeller M, Piazza-Waggoner C, Driscoll KA, Rothenberg ME, Franciosi J, Hommel KA. Health-related quality of life across pediatric chronic conditions. J Pediatr. 2010;156(4):639-44.

Rothenberg ME, Spergel JM, Sherrill JD, Annaiah K, Martin LJ, Cianferoni A, Gober L, Kim C, Glessner J, Fackelton E, Thomas K, Blanchard C, Liacouras C, Verma R, Aceves S, Collins MH, Brown-Whitehorn T, Putnam PE, Franciosi JP, Chiavacci RM, Grant SF, Abonia JP, Sleiman PM, Hakonarson H. Common variants at 5q22 associate with pediatric eosinophilic esophagitis. Nat Genet. 2010;42(4):289-91.

Vicario M, Blanchard C, Stringer KF, Collins MH, Mingler MK, Ahrens A, Putnam PE, Abonia JP, Santos J, Rothenberg ME. Local B cells and IgE production in the oesophageal mucosa in eosinophilic oesophagitis. Gut. 2010;59(1):12-20.


Krarup AL, Villadsen GE, Mejlgaard E, Olesen SS, Drewes AM, Funch-Jensen P. Acid hypersensitivity in patients with eosinophilic oesophagitis. Scand J Gastroenterol. 2010 Mar;45(3):273-281. This is an interesting manuscript that demonstrates that the esophagus of EE patients is hypersensitive to acid exposure (as measured by time to heartburn). Importantly, there is no differences in response to mechanical, thermal or electrical stimulation (markers of CNS sensitization), showing specificity of the response to acid. These results, combined with the recent findings that acid can increase eotaxin-3 release (Blanchard et al J Immunol; 2010;184:4033-41.), highlight the contribution of acid (reflux-associated acid or physiological acid) to EE. Based on this, the need to continue acid suppressive therapy in EE patients (regardless of GERD) should be considered.

Putnam PE, Rothenberg ME. Eosinophilic esophagitis: concepts, controversies, and evidence. Curr Gastroenterol Rep. 2009 Jun;11(3):220-5.

Qu Z, Kundu UR, Abadeer RA, Wanger A. Strongyloides colitis is a lethal mimic of ulcerative colitis: the key morphologic differential diagnosis. Hum Pathol. 2009 Apr;40(4):572-7. This article draws attention to the possibility that strongyloides infection can cause secondary eosinophilic colitis and should thus be in the differential diagnosis of EGID.

Brandt EB, Munitz A, Orekov T, Mingler MK, McBride M, Finkelman FD, Rothenberg ME. Targeting IL-4/IL-13 Signaling to Alleviate Oral Allergen-induced Diarrhea. J Allergy Clin Immunol. 2009 Jan;123(1):53-8.

Source Cincinnati Center for Eosinophilic Disorders, Cincinnati Children’s Hospital Medical Center Education


Landmark Discovery Reveals Cause of Eosinophilic Esophagitis

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Landmark Discovery Reveals Cause of Eosinophilic Esophagitis

View a message below from Dr. Marc Rothenberg of Cincinnati Children’s Hospital

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